The first Manchester derby of the season takes place on Saturday as Manchester City welcome United to the Etihad.
Manchester City sit third in the Premier League after a 4-1 win away at Burnley on Tuesday.
Gabriel Jesus scored twice, with Rodri and Riyad Mahrez also among the scorers in an easy win.
Manchester United recorded just a fifth league win of the season on Wednesday as they edged past Tottenham.
An in-form Marcus Rashford scored twice as they won 2-1 to move above Spurs in the league.
Premier League form: Manchester City W3 D1 L1; Manchester United W2 D2 L1
Premier League top scorers
Manchester City – Sergio Aguero 9 goals
Manchester United – Marcus Rashford 9 goals
Manchester City won both meetings last season, including a comfortable 3-1 win at the Etihad on route to the title.
Pep Guardiola has an excellent record at Old Trafford, but has won just one of the three league meetings at the Etihad.
Last five Premier League meetings
Manchester United 0 Manchester City 2 – 24/04/19
Manchester City 3 Manchester United 1 – 11/11/18
Manchester City 2 Manchester United 3 – 07/04/18
Manchester United 1 Manchester City 2 – 10/12/17
Manchester City 0 Manchester United 0 – 27/04/17
Ilkay Gundogan returns from suspension, but is unlikely to start here given the form of Rodri.
Angelino could keep his spot in the team with Benjamin Mendy enduring a difficult season.
Manchester United are likely to name the same XI that beat Tottenham, meaning Mason Greenwood will lead the line.
Neither Paul Pogba or Anthony Martial have been ruled out, however it’s very unlikely either will be fit to start.
Expected starting XI’s
Manchester City (4-3-3): Ederson; Walker, Stones, Fernandinho, Angelino; De Bruyne, Rodri, D.Silva; B.Silva, Jesus, Sterling
Manchester United (4-2-3-1): De Gea; Wan-Bissaka, Lindelof, Maguire, Young; McTominay, Fred; James, Lingard, Rashford; Greenwood
Result: Manchester City (3/10 with Bet 365)
Correct Score: 3-1 (11/1 with Bet 365)
Anytime Goalscorer: Raheem Sterling (6/5 with Coral)
Odds correct at time of article (23:00, 06/12) they are subject to change